کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5946335 1172358 2013 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Liberation of vessel-adherent myeloperoxidase reflects plaque burden in patients with stable coronary artery disease
ترجمه فارسی عنوان
آزادی ملپورکسیداز پایدار ماهیانه نشان دهنده پلاک در بیمارانی است که بیماری قلبی عروق کرونر پایدار دارند
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی

ObjectiveMyeloperoxidase (MPO) has emerged as an important pathophysiological determinant of inflammatory vascular artery disease. It is appreciated that vessel immobilized, rather than circulating, MPO is critical for the progression of atherosclerotic lesions. The objective of this study was to investigate whether vessel-immobilized MPO is associated with the extent of coronary plaque burden.MethodsMPO plasma levels were determined by ELISA before and after heparin-release of vessel-bound MPO, to study the relation between vascular MPO deposition and densitometrically assessed coronary plaque burden in 77 patients with stable coronary artery disease.ResultsPatients with a low increase in MPO plasma levels upon heparinization had a significantly smaller total plaque area and volume (12.1[IR:6.2-19.4]mm2 vs. 19.8[IR:11.3-31.5]mm2, p < 0.01; 27.8[IR:12.3-44.8]mm3 vs. 55.2[IR:24.2-87.5]mm3, p < 0.05). Multivariable linear regression revealed that ΔMPO was independently associated with plaque area, and that ΔMPO increased with the number of affected vessels. Selective sampling confirmed the predominant role of coronary MPO deposition.ConclusionOur data demonstrate that heparin-induced mobilization of vessel-bound MPO is closely linked to coronary plaque burden and thus further corroborate the evidence for the intimate involvement of this enzyme in vascular pathophysiology, as well as the importance of inflammation in atherosclerosis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Atherosclerosis - Volume 231, Issue 2, December 2013, Pages 354-358
نویسندگان
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