کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5947703 | 1172372 | 2013 | 5 صفحه PDF | دانلود رایگان |
ObjectiveGuidelines published in 2011 by the European Atherosclerosis Society and the European Society of Cardiology recommend a goal of either low-density lipoprotein cholesterol (LDL-C) <70 mg/dl (â¼1.8 mmol/l) or â¥50% reduction in LDL-C for patients at very high cardiovascular risk. The aim of this study was to determine the percentage of high-risk patients from the VOYAGER individual patient data meta-analysis treated with rosuvastatin 10-40 mg, atorvastatin 10-80 mg or simvastatin 10-80 mg who achieved this goal.MethodsWe analysed 25,075 patient exposures from high-risk patients. Paired comparisons were made between each rosuvastatin dose and an equal or higher dose of either atorvastatin or simvastatin, with a series of meta-analyses that included only randomised studies that directly compared rosuvastatin and its comparator treatments.ResultsAs statin dose increased, higher percentages of patients achieved LDL-C <70 mg/dl or â¥50% LDL-C reduction. A greater percentage achieved this goal with rosuvastatin 10-40 mg (43.8-79.0%) than with equal or double milligram doses of atorvastatin (16.1-65.2%) or simvastatin (0-39.7%).Paired comparisons showed statistically significant differences for: rosuvastatin 10 mg vs. atorvastatin 10-20 mg and simvastatin 10-20 mg; rosuvastatin 20 mg vs. atorvastatin 20-40 mg and simvastatin 20-80 mg; and rosuvastatin 40 mg vs. atorvastatin 40-80 mg and simvastatin 40-80 mg (all p < 0.001).ConclusionThese data from VOYAGER highlight the importance of an effective statin at an appropriate dose to achieve treatment goals for LDL-C in patients with very high cardiovascular risk.
⺠We analysed 2011 EAS/ESC guidelines on LDL-C goals for very high-risk patients. ⺠Information from the VOYAGER individual patient data meta-analysis was used. ⺠With high statin dose goal attainment (LDL-C <70 mg/dl or â¥50% reduction) improved. ⺠More reached goal with rosuvastatin than with equal/double doses of other statins. ⺠These data show the importance of using an effective statin at an appropriate dose.
Journal: Atherosclerosis - Volume 228, Issue 1, May 2013, Pages 265-269