13-year long-term associations between changes in traditional cardiovascular risk factors and changes in fibrinogen levels: The Coronary Artery Risk Development in Young Adults (CARDIA) study

► We determined 13-year associations between CVD risk factors and fibrinogen levels. ► Fibrinogen increased with development/worsening status of most CVD risk factors. ► Increase in fibrinogen for persons who quit smoking was comparable to never-smokers. ► Fibrinogen increase for those who lost weight was comparable to never-obese persons. ► Our study provides insight into the role of fibrinogen as a CVD risk marker.