کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5948116 | 1172376 | 2012 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Associations between serum lipoprotein(a) levels and the severity of coronary and aortic atherosclerosis
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کاردیولوژی و پزشکی قلب و عروق
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چکیده انگلیسی
To elucidate the associations between Lp(a) levels and coronary and aortic atherosclerosis, we performed aortic MRI in 143 patients undergoing coronary angiography. Severity of aortic atherosclerosis was represented as plaque scores. Of the 143 patients, 104 had coronary artery disease (CAD). Thoracic and abdominal aortic plaques were found in 89 and 131 patients. Lp(a) levels increased stepwise with the number of stenotic coronary vessels: 15.7 (CAD(â)), 21.2 (1-vessel), 21.4 (2-vessel), and 22.9Â mg/dl (3-vessel) (PÂ <Â 0.05). For aortic atherosclerosis, 143 patients were divided into quartiles by plaque scores. Lp(a) did not differ among quartiles of thoracic plaques: 17.1, 19.0, 23.5, and 21.2Â mg/dl (PÂ =Â NS), whereas Lp(a) increased stepwise with quartiles of abdominal plaques: 17.1, 19.2, 19.1, and 24.0Â mg/dl (PÂ <Â 0.05). Lp(a) was an independent factor for CAD and abdominal aortic plaques, but not thoracic plaques. Thus, Lp(a) levels were associated with aortic atherosclerosis, especially in abdominal aorta, as well as coronary atherosclerosis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Atherosclerosis - Volume 222, Issue 1, May 2012, Pages 241-244
Journal: Atherosclerosis - Volume 222, Issue 1, May 2012, Pages 241-244
نویسندگان
Yukihiko Momiyama, Reiko Ohmori, Zahi A. Fayad, Nobukiyo Tanaka, Ryuichi Kato, Hiroaki Taniguchi, Masayoshi Nagata, Fumitaka Ohsuzu,