کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5949455 1172388 2011 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Açaí juice attenuates atherosclerosis in ApoE deficient mice through antioxidant and anti-inflammatory activities
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Açaí juice attenuates atherosclerosis in ApoE deficient mice through antioxidant and anti-inflammatory activities
چکیده انگلیسی

ObjectiveAçaí fruit pulp has received much attention because of its high antioxidant capacity and potential anti-inflammatory effects. In this study, athero-protective effects of açaí juice were investigated in apolipoprotein E deficient (apoE−/−) mice.Methods and resultsApoE−/− mice were fed AIN-93G diet (CD) or CD formulated to contain 5% freeze-dried açaí juice powder (AJ) for 20 weeks. The mean lesion areas in the aorta for apoE−/− mice fed AJ were 58% less (P < 0.001) compared to that for CD fed mice. HDL-cholesterol was higher in AJ fed mice. Biomarkers of lipid peroxidation, including F2-isoprostanes and isomers of hydroxyoctadecadienoic acids and hydroxyeicosatetraenoic acids were significantly lower in serum and in liver of AJ fed mice. Expression of the two antioxidant enzyme genes, Gpx3 and Gsr, were significantly up-regulated in the aorta from AJ fed mice. The activity of GPX, GSR and PON1 increased in serum and/or liver of mice fed AJ. In the second experiment, ApoE−/− mice were fed CD or AJ for 5 weeks. Serum levels, gene expression and protein levels of the two proinflammatory cytokines TNF-α and IL-6 in the resident macrophages with or without LPS stimulation were lower in mice fed AJ. SEAP reporter assay determined that AJ reduced NF-κB activation.ConclusionReducing lipid peroxidation through boosting antioxidant enzymes and inhibiting pro-inflammatory cytokine production are proposed as major underlying mechanisms for the athero-protective effects of the açaí juice tested in these experimental in vivo models.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Atherosclerosis - Volume 216, Issue 2, June 2011, Pages 327-333
نویسندگان
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