کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
595679 1454019 2010 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Optimization of nanostructured lipid carriers for lutein delivery
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی شیمی کلوئیدی و سطحی
پیش نمایش صفحه اول مقاله
Optimization of nanostructured lipid carriers for lutein delivery
چکیده انگلیسی
Nanostructured lipid carrier (NLC) systems were developed using response surface methodology to optimize the concentrations of lipophilic and hydrophilic surfactants based on the size of the resulting NLC. From preliminary experiments, a formulation composed of Precirol, Myverol, and Pluronic formed a stable NLC dispersion. Concentrations of the surfactants, Myverol and Pluronic, were optimized by a central composite design and response surface methodology. Lutein (phylloquinone) was used as a lipophilic drug in the NLC system. The particle size and polydispersion index of the NLC were measured using photon correlation spectroscopy. The ultrasonication duration and drug load were found to significantly impact the particle size of the NLCs prepared. The prepared NLCs were examined by differential scanning calorimetry (DSC), X-ray diffraction (XRD), and transmission electron microscopy (TEM) and found to have an imperfect crystalline lattice and a spherical morphology. The lutein-loaded NLCs had high release rates of the drug in simulated intestinal fluid compared to simulated gastric fluid using modified Franz diffusion cells. Sustained-release lutein delivery was achieved using NLC technology.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Colloids and Surfaces A: Physicochemical and Engineering Aspects - Volume 353, Issues 2–3, 15 January 2010, Pages 149-156
نویسندگان
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