کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5960249 | 1175818 | 2015 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Small-conductance Ca2+-activated K+ channels and cardiac arrhythmias
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
MLC2PP2APSCAERPSANEADAPDCK2Atrial arrhythmia - آریتمی دهلیزیearly afterdepolarization - اوایل پس از دپولیزاسیونantiarrhythmic drug - داروهای ضد آرتریتatrial effective refractory period - دوره انجماد مفاصل دهانpulmonary vein - رگ ریویCAM - ساخت به کمک کامپیوترPluripotent stem cell - سلول های بنیادی پلوروپتوژنAtrial fibrillation - فیبریلاسیون دهلیزیAction potential duration - مدت زمان بالقوه عملheart failure - نارسایی قلبیaction potential - پتانسیل عمل Proarrhythmia - پرواریتریومprotein phosphatase 2A - پروتئین فسفاتاز 2Acasein kinase II - کازئین کیناز IICalmodulin - کالمودولینCalcium-activated potassium channel - کانال پتاسیم فعال کلسیمSinoatrial node - گره Sinoatrial
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Small-conductance Ca2+-activated K+ (SK, KCa2) channels are unique in that they are gated solely by changes in intracellular Ca2+ and, hence, function to integrate intracellular Ca2+ and membrane potentials on a beat-to-beat basis. Recent studies have provided evidence for the existence and functional significance of SK channels in the heart. Indeed, our knowledge of cardiac SK channels has been greatly expanded over the past decade. Interests in cardiac SK channels are further driven by recent studies suggesting the critical roles of SK channels in human atrial fibrillation, the SK channel as a possible novel therapeutic target in atrial arrhythmias, and upregulation of SK channels in heart failure in animal models and in human heart failure. However, there remain critical gaps in our knowledge. Specifically, blockade of SK channels in cardiac arrhythmias has been shown to be both antiarrhythmic and proarrhythmic. This contemporary review provides an overview of the literature on the role of cardiac SK channels in cardiac arrhythmias and serves as a discussion platform for the current clinical perspectives. At the translational level, development of SK channel blockers as a new therapeutic strategy in the treatment of atrial fibrillation and the possible proarrhythmic effects merit further considerations and investigations.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Heart Rhythm - Volume 12, Issue 8, August 2015, Pages 1845-1851
Journal: Heart Rhythm - Volume 12, Issue 8, August 2015, Pages 1845-1851
نویسندگان
Xiao-Dong PhD, Deborah K. PhD, Nipavan MD,