کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5961931 | 1175896 | 2009 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Vagal stimulation for heart failure: Background and first in-man study
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کلمات کلیدی
BRSNYHAMyocardial infarction - آنفارکتوس میوکاردNew York Heart Association - انجمن قلب نیویورکLeft ventricular - بطن چپBaroreflex sensitivity - حساسیت BaroreflexAutonomic nervous system - دستگاه عصبی خودمختار یا خودگردان یا اتونومvagus nerve - عصب واگVentricular fibrillation - فیبریلاسیون بطنیheart failure - نارسایی قلبیCardiomyopathy - کاردیومیوپاتی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کاردیولوژی و پزشکی قلب و عروق
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چکیده انگلیسی
This article reviews the background and rationale that have led to the first in-man study of the effects of direct chronic vagal stimulation for the management of heart failure. Following a brief discussion of the concept of “autonomic imbalance,” the focus shifts to the wealth of pathophysiologic information gathered over the years by the in-depth study of an animal model for sudden cardiac death. These data, on the bleak prognostic outcome associated with the presence of depressed vagal reflexes in both animals and men and on the striking reversal in outcome produced in high-risk dogs by direct vagal stimulation, made logical the move toward a human study. The data of the first pilot trial in man are presented and reviewed. The study population consisted of eight patients with advanced heart failure who underwent implantation of a neurostimulator system capable of delivering low-current electrical pulses to stimulate the right vagus nerve. These initial data suggest that chronic vagal stimulation in man is feasible and safe. Furthermore, in this pilot study, the treatment appears to be associated with beneficial effects.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Heart Rhythm - Volume 6, Issue 11, Supplement, November 2009, Pages S76-S81
Journal: Heart Rhythm - Volume 6, Issue 11, Supplement, November 2009, Pages S76-S81
نویسندگان
Peter J. MD, FHRS, Gaetano M. MD,