کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
597233 1454064 2007 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Preparation of temperature-sensitive microemulsion-based gels formed from a triblock copolymer
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی شیمی کلوئیدی و سطحی
پیش نمایش صفحه اول مقاله
Preparation of temperature-sensitive microemulsion-based gels formed from a triblock copolymer
چکیده انگلیسی

Temperature-sensitive microemulsion-based gels (MBGs) of Pluronic F127 (PEO99–PPO67–PEO99) were formed in microemulsion systems composed of isopropyl myristate (IPM)/Span20/Tween20/H2O, with or without a model drug (chloramphenicol), and the phase behaviors of the systems were investigated. The viscoelastic properties and gelation temperatures of the systems were characterized by rheological measurements. Effects of the concentration of F127 and the model drug (chloramphenicol) on the viscoelastic properties and gelation temperatures were also studied. It was observed that the viscosities of the gels increased and the gelation temperatures decreased with increasing F127 concentration. Chloramphenicol had little effect on the viscosities and gelation temperatures of the MBG. Moreover, chloramphenicol was sustainably released from the MBG system. Freeze-fracture transmission electron microscopy (FF-TEM) demonstrated that the amphiphilic triblock copolymer (F127) self-assembled in the selected microemulsion system and formed network structures. The microstructures of the microemulsion droplets were maintained in the MBG after the addition of F127. The results of fluorescence spectroscopy also supported this conclusion. Based on these results, a plausible schematic model was proposed to explain the mechanism of MBG formation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Colloids and Surfaces A: Physicochemical and Engineering Aspects - Volume 307, Issues 1–3, 15 October 2007, Pages 100–107
نویسندگان
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