کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5982838 1577081 2014 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Fasting Levels of High-Sensitivity Growth Hormone Predict Cardiovascular Morbidity and Mortality: The Malmö Diet and Cancer Study
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Fasting Levels of High-Sensitivity Growth Hormone Predict Cardiovascular Morbidity and Mortality: The Malmö Diet and Cancer Study
چکیده انگلیسی

BackgroundBoth pathological excess and deficiency of growth hormone (GH) are associated with cardiovascular mortality.ObjectivesThe goal of this study was to test whether fasting levels of growth hormone measured with a high-sensitivity assay (hs-GH) predict cardiovascular morbidity and mortality at the population level.MethodsWe studied 4,323 participants (age 46 to 68 years; mean age 58 years; 59% women) of the Swedish, population-based Malmö Diet and Cancer study examined in 1991 to 1994. Using multivariate-adjusted Cox proportional hazards models, we related baseline levels of fasting hs-GH to incidence of coronary artery disease, stroke, congestive heart failure, all-cause mortality, and cardiovascular mortality.ResultsDuring a median follow-up of 16.2 years, hs-GH (hazard ratio [HR]/SD increment of natural logarithm of fasting hs-GH) was independently associated with increased risk of coronary artery disease (397 events; HR: 1.11; 95% confidence interval [CI]: 1.01 to 1.23; p = 0.04), stroke (251 events; HR: 1.18; 95% CI: 1.04 to 1.34; p = 0.01), congestive heart failure (107 events; HR: 1.25; 95% CI: 1.03 to 1.52; p = 0.02), all-cause mortality (645 events; HR: 1.17; 95% CI: 1.08 to 1.26; p < 0.001) and cardiovascular mortality (186 events; HR: 1.43; 95% CI: 1.24 to 1.66; p < 0.001). The addition of hs-GH to a model with conventional cardiovascular risk factors significantly reclassified risk, with a category-free net reclassification improvement (>0) of 0.542 (95% CI: 0.205 to 0.840) in cardiovascular mortality.ConclusionsHigher values of hs-GH were associated with an increased risk of cardiovascular morbidity and mortality.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the American College of Cardiology - Volume 64, Issue 14, 7 October 2014, Pages 1452-1460
نویسندگان
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