کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5984435 1178586 2016 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Long-term myocardial toxicity in a patient with tizanidine and etizolam overdose
ترجمه فارسی عنوان
سمیت طولانی مدت سکته قلبی در بیماران مبتلا به تیزانیدین و تجویز پروتئین اتیلولام
کلمات کلیدی
 ± 2-گیرنده گیرنده، سمیت طولانی مدت سکته قلبی، آریتمی بطنی کشنده
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی

Tizanidine hydrochloride, α2-receptor stimulant, is a central muscle relaxant. Etizolam is a benzodiazepine-based anti-anxiety agent. Both drugs are widely used for the treatment of a variety of muscle pain and frequently used together in Japan. We experienced a case of complicating prolonged myocardial dysfunction in a 56-year-old woman. Six hours after overdose of 48 mg tizanidine and 24 mg etizolam, she showed sinus bradycardia and peripheral vascular resistance decreasing shock. At that time new ST-T depressions were recognized in electrocardiography (ECG); however, structural heart diseases were interpreted as negative by other examinations. Intravenous norepinephrine infusion was useful to maintain the hemodynamic stability. ECG reversed to normal findings on day 14; however, the cardiac nuclear medicine studies on day 30 showed severe fatty metabolic disorder and sympathetic denervation. Non-sustained ventricular tachycardia was detected. Complete recovery of the myocardium damage required one year. For one mechanism, it was suggested that over-stimulation of α2-receptor by tizanidine inhibited the norepinephrine secretion and reuptake at pre-synaptic surface of adipose cell and cardiac sympathetic nerve. We want to suggest that the cardiologist should consider the risk of fatal arrhythmia and long-term myocardium toxicity as the poisoning of the central muscle relaxant and benzodiazepine agent.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Cardiology Cases - Volume 13, Issue 3, March 2016, Pages 78-81
نویسندگان
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