Awareness, overestimation, and underestimation of cognitive functions in epilepsy

This study estimated cognitive awareness and the predictors of self-rating in patients with epilepsy (PWE). The Multiple Ability Self-Report Questionnaire (MASQ), State-Trait Anxiety Inventory, and Beck Depression Inventory were used for self-evaluation. Neuropsychological assessment yielded five single-domain scores (Long-Term Memory, Mental Speed, Working Memory, Set Shifting, and Visuospatial Matching) and a total composite score. Awareness was computed as the concordance between the neuropsychological and MASQ scores. In 37 patients with full awareness, self-ratings were predicted by Long-Term Memory, Working Memory, and Mental Speed. In 58 patients with incomplete or no awareness, self-ratings related to depression and seizure frequency. Compared with overestimation, underestimation was associated with higher test scores, better education, and younger age. Brain lesion and the type of epilepsy showed no effect. Therefore, PWE may appear unaware of their cognitive abilities due to negative affect and clinical burden. Understanding patients' awareness of their cognitive deficits can help clarify the clinical pattern provoked by epilepsy, as well as patients' compliance with treatment for seizures or cognitive difficulties.

► Awareness was defined as concordance between self-rated and objective functions. ► Sixty-one percent of patients showed incomplete or no awareness. ► Unawareness was explained by psychological and clinical variables. ► Neuropsychological performances predicted cognitive self-ratings in aware patients.