کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6013720 | 1185920 | 2012 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Pregabalin intoxication-induced encephalopathy with triphasic waves
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
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چکیده انگلیسی
This report documents the case of a 79-year-old woman presenting with encephalopathy and triphasic waves (TWs) due to pregabalin (PGB) intoxication. For the two years prior to admission, she had taken PGB to treat post-herpetic neuralgia. Brain MRI revealed mild leukoaraiosis and cortical atrophy. Electroencephalography showed continuous frontal-dominant TWs. These TWs were suppressed by intravenous lorazepam, but mental function was not improved. Laboratory tests revealed prerenal azotemia, which may elevate serum PGB and cause toxic encephalopathy with TWs. After fluid therapy and discontinuation of PGB, mental status recovered completely and TWs disappeared. I conclude that PGB intoxication due to deficient renal clearance can cause a reversible encephalopathy with TWs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Epilepsy & Behavior - Volume 25, Issue 2, October 2012, Pages 170-173
Journal: Epilepsy & Behavior - Volume 25, Issue 2, October 2012, Pages 170-173
نویسندگان
Sejin Lee,