Long-term outcomes from the PEARLS randomized trial for the treatment of depression in patients with epilepsy

► Long-term outcomes of depression treatment in epilepsy have not been reported. ► The PEARLS intervention resulted in reduction in depression symptoms. ► The PEARLS intervention resulted in reduction in suicidal ideation. ► The PEARLS intervention resulted in improvement in emotional well-being. ► This improvement persisted to the 18-month follow-up.