کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6017461 1580168 2015 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A novel and robust conditioning lesion induced by ethidium bromide
ترجمه فارسی عنوان
ضایعه جدید و قوی تهویه مطبوع بوسیله اتیدیم برومید
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
چکیده انگلیسی
Molecular and cellular mechanisms underlying the peripheral conditioning lesion remain unsolved. We show here that injection of a chemical demyelinating agent, ethidium bromide, into the sciatic nerve induces a similar set of regeneration-associated genes and promotes a 2.7-fold greater extent of sensory axon regeneration in the spinal cord than sciatic nerve crush. We found that more severe peripheral demyelination correlates with more severe functional and electrophysiological deficits, but more robust central regeneration. Ethidium bromide injection does not activate macrophages at the demyelinated sciatic nerve site, as observed after nerve crush, but briefly activates macrophages in the dorsal root ganglion. This study provides a new method for investigating the underlying mechanisms of the conditioning response and suggests that loss of the peripheral myelin may be a major signal to change the intrinsic growth state of adult sensory neurons and promote regeneration.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Neurology - Volume 265, March 2015, Pages 30-39
نویسندگان
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