کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6018112 | 1580184 | 2013 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The late response of rat subependymal zone stem and progenitor cells to stroke is restricted to directly affected areas of their niche
ترجمه فارسی عنوان
پاسخ دیرهنگام ساقه و سلول پیشرونده ناحیه موشهای سائیدگی موش به سکته مغزی محدود به مناطق مستقیما آسیب دیده از طاقچه آنها است
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
عصب شناسی
چکیده انگلیسی
Ischaemia leads to increased proliferation of progenitors in the subependymal zone (SEZ) neurogenic niche of the adult brain and to generation and migration of newborn neurons. Here we investigated the spatiotemporal characteristics of the mitotic activity of adult neural stem and progenitor cells in the SEZ during the sub-acute and chronic post-ischaemic phases. Ischaemia was induced by performing a 1Â h unilateral middle cerebral artery occlusion (MCAO) and tissue was collected 4/5Â weeks and 1Â year after the insult. Neural stem cells (NSCs) responded differently from their downstream progenitors to MCAO, with NSCs being activated only transiently whilst progenitors remain activated even at 1Â year post-injury. Importantly, mitotic activation was observed only in the affected areas of the niche and specifically in the dorsal half of the SEZ. Analysis of the topography of mitoses, in relation to the anatomy of the lesion and to the position of ependymal cells and blood vessels, suggested an interplay between lesion-derived recruiting signals and the local signals that normally control proliferation in the chronic post-ischaemic phase.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Neurology - Volume 248, October 2013, Pages 387-397
Journal: Experimental Neurology - Volume 248, October 2013, Pages 387-397
نویسندگان
Ilias Kazanis, Natalia Gorenkova, Jing-Wei Zhao, Robin J.M. Franklin, Michel Modo, Charles ffrench-Constant,