Serotonergic pharmacotherapy promotes cortical reorganization after spinal cord injury

► Since spinal cord injury induces cortical reorganization, ► We tested the effects of 5-HT therapy on cortical reorganization. ► Results show more reorganization in the hindlimb sensorimotor cortex than SCI alone. ► Reorganization was dose dependent and extended into intact (forelimb) motor cortex. ► Reorganization was correlated to behavioral outcome.