Intranasal delivery of cell-penetrating anti-NF-κB peptides (Tat-NBD) alleviates infection-sensitized hypoxic-ischemic brain injury

► Infection drastically alters pathogenic mechanism of hypoxic-ischemic brain injury. ► Intranasal delivery of anti NFkB peptides blocks infection sensitized HI injury. ► Results suggest a safe, brain targeted anti neuroinflammatory therapy.