Human nasal olfactory epithelium as a dynamic marker for CNS therapy development

► Use of nasal biopsies as a surrogate marker for drug effects in the CNS. ► Astrocytic proteins expressed in human peripheral olfactory epithelial tissue. ► Glutamate transporter upregulating agents increase transporter mRNA in human olfactory epithelial tissue samples. ► Nasal biopsies can be reliably and safely employed in human clinical trials.