Rapid epileptogenesis in the mouse pilocarpine model: Video-EEG, pharmacokinetic and histopathological characterization

► We have characterized pilocarpine model of epileptogenesis in mice. ► Generalized seizures started already 24 h after pilocarpine status epilepticus. ► These seizures were not related to any residual pilocarpine exposure. ► Hippocampal damage is correlated with status epilepticus duration and seizure numbers. ► Mouse pilocarpine model may be used for the discovery of novel epilepsy therapies.