Peri-sciatic administration of recombinant rat IL-1β induces mechanical allodynia by activation of src-family kinases in spinal microglia in rats

► Peri-sciatic administration of rrIL-1β induced mechanical allodynia. ► RrIL-1β activated SFKs in microglia in lumbar spinal dorsal horn. ► Minocycline or SFKs inhibitor prevented allodynia induced by rrIL-1β.