Transient striatal GLT-1 blockade increases EAAC1 expression, glutamate reuptake, and decreases tyrosine hydroxylase phosphorylation at ser19

► Striatal GLT-1 blockade decreased ser19 phosphorylation of tyrosine hydroxylase. ► Increased EAAC1 protein expression follows striatal GLT-1 blockade. ► Increased GLAST-mediated glutamate reuptake follows striatal GLT-1 blockade.