Protection from diabetes-induced peripheral sensory neuropathy - A role for elevated glyoxalase I?

►Glyoxalase I protects against damaging effects of advanced glycation end products. ►We examine two strains of mice that naturally express different levels of GLO1. ►Diabetic BALB/cJ mice with low levels develop several classic signs of neuropathy. ►Diabetic BALB/cByJ mice with high levels do not develop signs of neuropathy. ►These mice provide a new tool to explore the role of GLO1 and AGE-related damage.