BACE1 elevation is associated with aberrant limbic axonal sprouting in epileptic CD1 mice

► Epilepsy and Alzheimer's disease are often comorbid conditions. ► BACE1 is an enzyme involved in generating β-amyloid, a component of senile plaques. ► BACE1 was elevated in chronically epileptic mouse hippocampus. ► Increases in GAP-43 and PSA-NCAM colocalized with elevated BACE1. ► BACE1 may be involved in pathology-induced axon sprouting.