Hemodynamic monitoring of intracranial collateral flow predicts tissue and functional outcome in experimental ischemic stroke

► Collaterals' hemodynamics can be effectively studied by multi-site laser Doppler. ► Collaterals' functional performance is highly correlated with infarct volume. ► Collaterals' functional performance is highly correlated with functional deficit. ► Monitoring collaterals' hemodynamics is essential for reducing stroke variability.