Effect of globus pallidus internus stimulation on neuronal activity in the pedunculopontine tegmental nucleus in the primate model of Parkinson's disease

► We examined the effect of GPi DBS on PPN neuronal activity in the MPTP monkey. ► Single neuron activity was recorded from the PPN before, during, and after GPi DBS. ► Therapeutic GPi DBS reduced the mean discharge rate of PPN neurons. ► Therapeutic GPi DBS increased low frequency oscillatory neuronal activity.