Wind-up of stretch reflexes as a measure of spasticity in chronic spinalized rats: The effects of passive exercise and modafinil

►Stretch reflexes demonstrate wind-up in spinal cord injured rats. ►Passive exercise prevents stretch reflex wind-up and restores frequency dependent depression of the H-reflex. ►Modafinil prevents stretch reflex wind-up and restores frequency dependent depression of the H-reflex.