کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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6020574 | 1580400 | 2014 | 10 صفحه PDF | دانلود رایگان |
- The association between IL-6 and stroke outcome was quantified by meta-analysis.
- We retrieved individual data from 20 studies including 4,112 stroke patients.
- IL-6 was independently associated with poor outcome and post-stroke infection.
- Addition of IL-6 to predictive clinical models slightly improved its prediction.
- Isolated IL-6 determination in stroke seems not useful for outcome prediction.
We aimed to quantify the association of blood interleukin-6 (IL-6) concentrations with poor outcome after stroke and its added predictive value over clinical information. Meta-analysis of 24 studies confirmed this association with a weighted mean difference of 3.443 (1.592-5.294) pg/mL, despite high heterogeneity and publication bias. Individual participant data including 4112 stroke patients showed standardized IL-6 levels in the 4th quartile were independently associated with poor outcome (OR = 2.346 (1.814-3.033), p < 0.0001). However, the additional predictive value of IL-6 was moderate (IDI = 1.5%, NRI = 5.35%). Overall these results indicate an unlikely translation of IL-6 into clinical practice for this purpose.
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Journal: Journal of Neuroimmunology - Volume 274, Issues 1â2, 15 September 2014, Pages 215-224