کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6021157 | 1580440 | 2011 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cold stress induced morphological microglial activation and increased IL-1β expression in astroglial cells in rat brain
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Cold stress induced morphological microglial activation and increased IL-1β expression in astroglial cells in rat brain Cold stress induced morphological microglial activation and increased IL-1β expression in astroglial cells in rat brain](/preview/png/6021157.png)
چکیده انگلیسی
The present study investigated the possible impact of cold stress on the immune functions of the brain. Wistar rats were exposed to 4 °C for 2 h prior to analysis of immunohistochemical analysis of OX-42 and IL-1β, which are markers of microglia and inflammation, respectively. Exposure to cold stress induced morphological microglial activation in as early as 30 min, and the activation lasted up to 2 h following the stress. In addition, increased IL-1β-immunoreactivity was detected in the hippocampus and hypothalamus. However, IL-1β was not co-localized with microglia, and was predominantly expressed in astroglia. The present study provides the first evidence that cold stress contributes to neuro-immunomodulation in the brain through microglial activation and expression of IL-1β in astroglia.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 233, Issues 1â2, April 2011, Pages 29-36
Journal: Journal of Neuroimmunology - Volume 233, Issues 1â2, April 2011, Pages 29-36
نویسندگان
Shuei Sugama, Takato Takenouchi, Masayo Fujita, Hiroshi Kitani, Makoto Hashimoto,