کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6022217 | 1580666 | 2013 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Maternal choline supplementation improves spatial learning and adult hippocampal neurogenesis in the Ts65Dn mouse model of Down syndrome
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کلمات کلیدی
(NGF)(TBS)(DS)(BDNF)Ts65Dnphosphate buffer - بافر فسفاتTris-buffered saline - تریس بافر شورdoublecortin - دوچرخهpostnatal day - روز پس از زایمانDown syndrome - سندرم داونdentate gyrus - شکنج دندانه دارnerve growth factor - فاکتور رشد عصبbrain-derived neurotropic factor - فاکتور نوروتروپیک مغز استخراج شدهbasal forebrain cholinergic neurons - نورونهای کولینرژیک مغز پایهNeurogenesis - نوروژنزHippocampus - هیپوکامپ Human chromosome 21 - کروموزوم انسانی 21mouse chromosome 16 - کروموزوم موش 16Spatial learning - یادگیری فضایی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
عصب شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Maternal choline supplementation improves spatial learning and adult hippocampal neurogenesis in the Ts65Dn mouse model of Down syndrome Maternal choline supplementation improves spatial learning and adult hippocampal neurogenesis in the Ts65Dn mouse model of Down syndrome](/preview/png/6022217.png)
چکیده انگلیسی
In addition to intellectual disability, individuals with Down syndrome (DS) exhibit dementia by the third or fourth decade of life, due to the early onset of neuropathological changes typical of Alzheimer's disease (AD). Deficient ontogenetic neurogenesis contributes to the brain hypoplasia and hypocellularity evident in fetuses and children with DS. A murine model of DS and AD (the Ts65Dn mouse) exhibits key features of these disorders, notably deficient ontogenetic neurogenesis, degeneration of basal forebrain cholinergic neurons (BFCNs), and cognitive deficits. Adult hippocampal (HP) neurogenesis is also deficient in Ts65Dn mice and may contribute to the observed cognitive dysfunction. Herein, we demonstrate that supplementing the maternal diet with additional choline (approximately 4.5 times the amount in normal rodent chow) dramatically improved the performance of the adult trisomic offspring in a radial arm water maze task. Ts65Dn offspring of choline-supplemented dams performed significantly better than unsupplemented Ts65Dn mice. Furthermore, adult hippocampal neurogenesis was partially normalized in the maternal choline supplemented (MCS) trisomic offspring relative to their unsupplemented counterparts. A significant correlation was observed between adult hippocampal neurogenesis and performance in the water maze, suggesting that the increased neurogenesis seen in the supplemented trisomic mice contributed functionally to their improved spatial cognition. These findings suggest that supplementing the maternal diet with additional choline has significant translational potential for DS.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Disease - Volume 58, October 2013, Pages 92-101
Journal: Neurobiology of Disease - Volume 58, October 2013, Pages 92-101
نویسندگان
Ramon Velazquez, Jessica A. Ash, Brian E. Powers, Christy M. Kelley, Myla Strawderman, Zoe I. Luscher, Stephen D. Ginsberg, Elliott J. Mufson, Barbara J. Strupp,