Subtle microstructural changes of the striatum in a DYT1 knock-in mouse model of dystonia

► Striatal cholinergic neurons were enlarged in a mouse model of DYT1 dystonia. ► Striatal parvalbumin + neurons were enlarged in the mutant mice. ► Striatal nNOS + neurons were smaller in the mutant mice. ► Striatal medium spiny neurons had fewer dendrites and smaller spines in the mutants. ► The ratio of axo-spinous to axo-dendritic synapses was reduced in the mutant mice.