Predictive neural biomarkers of clinical response in depression: A meta-analysis of functional and structural neuroimaging studies of pharmacological and psychological therapies

► Cingulate hyperactivity predicts positive antidepressant response ► Increased activity in insula and striatum predicts poor response. ► Decreased right hippocampal volume increases the likelihood of poor response ► Predictive brain scan information is both multimodal and regionally distributed. ► Clinical prediction of response should integrate these distributed markers.