Normalization of Dyrk1A expression by AAV2/1-shDyrk1A attenuates hippocampal-dependent defects in the Ts65Dn mouse model of Down syndrome

► Normalization of Dyrk1A levels was achieved in trisomic mice using viral particles. ► Dyrk1A normalization attenuates hippocampal phenotype in adult trisomic mice. ► Dyrk1A is a potential target in adult trisomic mouse models of Down syndrome.