Cerebellar defects in Pdss2 conditional knockout mice during embryonic development and in adulthood

► Pdss2 knockout in the developing cerebellum causes cerebellum hypoplasia. ► Pdss2 knockout retards the growth of radial glial cells and impairs cell migration. ► Pdss2 knockout may trigger apoptosis via defective mitochondria. ► Pdss2 knockout in Purkinje cells after birth may lead to cerebellar ataxia.