Genetically encoded redox sensor identifies the role of ROS in degenerative and mitochondrial disease pathogenesis

► Genetically encoded mitochondrial redox sensors in vivo. ► Mitochondrial redox status increases with age suggesting a role in aging/senescense. ► Progressive mitochondrial redox changes in mitochondrial encephalopathy in vivo. ► Mitochondrial ROS associated with Na/K ATPase neurodegeneration in vivo.