Early life stress triggers sustained changes in histone deacetylase expression and histone H4 modifications that alter responsiveness to adolescent antidepressant treatment

► Early life stress leads to changes in histone modifications in adulthood. ► These histone modifications are predominant in the frontal cortex of young adults. ► The histone modifications blunt the severity of abnormal emotive behavior. ► The histone modifications enhance responses to adolescent antidepressant treatment.