Role of mTOR in neuroprotection and axon regeneration after inflammatory stimulation

► Inflammatory stimulation or CNTF enhance mTOR activity in RGCs in vivo and in vitro. ► mTOR activation is mediated by astrocytic CNTF and LIF after inflammatory stimulation. ► Neuronal mTOR activity is not required in neuroprotection and initiation of axon regeneration. ► Neuronal mTOR activity is required for the maintenance of the regenerative state. ► Neuronal mTOR activity modulates inhibitory signaling of myelin and neurocan.