c-Jun-dependent sulfiredoxin induction mediates BDNF protection against mitochondrial inhibition in rat cortical neurons

► BDNF induction of c-Jun requires prior phosphorylation of ERK1/2. ► BDNF induction of sulfiredoxin requires ERK1/2 activation and c-Jun expression. ► Blockade of ERK1/2, c-Jun, and sulfiredoxin abolishes BDNF neuroprotection. ► BDNF → ERK1/2-Pi → c-Jun → sulfiredoxin → 3-NP resistance.