Keywords: Thyroid hormones; 3, 5-Diiodothyronine; 3-Iodothyronamine; Thyroacetic acids; Non-genomic effects; Cardioprotection; ADP; adenosine diphosphate; Akt; Ak strain transforming; Ang II; angiotensin II; ATP; adenosine triphosphate; CaM; calmodulin; D2; type II
مقالات ISI (ترجمه نشده)
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Keywords: Synergy; Ferulic acid; Metformin; Anti-diabetic agents; AMPK, PI-3K; Akt; protein kinase B; AMPK; AMP-activated protein kinase; DM; Diabetes mellitus; G6Pase; glucose-6-phosphatase; IRS; Insulin receptor substrate; LD50; lethal dose 50%; PDK-1; 3-phosphoi
Keywords: mPTP; mitochondrial Permeability Transition Pore; CRC; Calcium Retention Capacity; C; Control; C/S; Control with Stress; C+Cn; Control plus Cinnamon; C+Cn/S; Control plus Cinnamon with Stress; HF2; High Fat/High Fructose; HF2/S; High Fat/High Fructose wit
Keywords: AUC; area under the curve; BB-DP; BioBreeding Diabetes-Prone; BB/OK; BioBreeding/Ottawa Kalsburg; cDM; canine diabetes mellitus; DM; diabetes mellitus; DLA; Dog Leukocyte Antigen; FPG; fasting plasma glucose; GIR; glucose infusion rate; GTT; glucose toler
Keywords: Antibodies; Immunoconjugates; Immunotoxins; Ab; antibody; Ag; antigen; ADCC; antibody-dependent cell mediated cytotoxicity; ALL; acute lymphoblastic leukemia; AML; acute myeloid leukemia; AKT; protein kinase B; APC; antigen-presenting cell; Apo2L/TRAIL; t
Keywords: ATM; ataxia telangiectasia-mutated kinase; ATR; ataxia telangiectasia and Rad3-related kinase; CI; combination index; CLL; chronic lymphocytic leukemic cells; DNA-PK; DNA-dependent protein kinase; DNA-PKcs; DNA-dependent protein kinase catalytic subunit;
Keywords: VEGF; vascular endothelial growth factor; VEGF-R1; vascular endothelial growth factor receptor 1; VEGF-R2; vascular endothelial growth factor receptor 2; SCI; spinal cord injury; dextran-TMR; dextran tetramethylrhodamine; PI3-K; phosphatidylinositide 3-ki
Keywords: 4-HNE; 4-hydroxy-2-nonenal; AMPK; AMP-activated kinase; CaMK; Ca2+/calmodulin-dependent protein kinase; CK; creatine kinase; GLUT4; glucose transporter 4; IKK; IκB kinase; IL; interleukin; IRS; insulin receptor substrate; MAPK; mitogen-activated protein
Keywords: ASDH; acute subdural hemorrhage; BBB; blood-brain-barrier; CBF; cerebral blood flow; EPO; erythropoietin; EPOR; erythropoietin receptor; HHT; hyperoncotic/hypertonic solution treatment; ICP; intracranial pressure; LDU; Laser-Doppler units; MAP; mean art
Molecular characterization and expression analysis of interferon-gamma in black seabream Acanthopagrus schlegelii
Keywords: Black seabream; IFN-gamma; Red spotted grouper nervous necrosis virus; JAK-STAT; ISG; AP-1; activator protein 1; bp; base pair; CaMKII; calcium/calmodulin kinase II; GAS; gamma IFN-activated sequences; ORF; open reading frame; GATA3; GATA-binding protein
Supplementation with Vitis vinifera L. skin extract improves insulin resistance and prevents hepatic lipid accumulation and steatosis in high-fat diet-fed mice
Keywords: Grape skin, polyphenols; Hepatic steatosis; Insulin resistance, oxidative stress; ABCG5; ATP-biding cassette, subfamily G transporter 5; ABCG8; ATP-biding cassette, subfamily G transporter 8; ACH09; grape skin extract; AMPK; adenosine-monophosphate-acti
Functions of Rho family of small GTPases and Rho-associated coiled-coil kinases in bone cells during differentiation and mineralization
Keywords: AGC; protein kinase A, G, and C families (PKA, PKC, PKG) of cytoplasmic serine/threonine kinases; AnxA; vertebrate annexin; ALP; alkaline phosphatase; ANK; progressive ankylosis protein; BMP; bone morphogenetic protein; BSP; bone sialoprotein; CHOL; chole
Modulation of ionizing radiation-induced effects by NU7441, KU55933 and VE821 in peripheral blood lymphocytes
Keywords: Ionizing radiation; Lymphocytes; KU55933; NU7441; VE821; ATM; ataxia-telangiectasia mutated kinase; ATR; ataxia telangiectasia and Rad3-related protein kinase; DMSO; dimethyl sulfoxide; DNA-PK; DNA-dependent protein kinase; DSB; double strand break; Gy; g
The role of epsilon PKC in acute and chronic diseases: Possible pharmacological implications of its modulators
Keywords: PKC; protein kinase C; IPC; ischemic pre conditioning; RACK; receptor for activated C-kinase; DAG; diacylglycerol; beta COP; coatomer subunit beta; CHOK1; chinese hamster ovary K1; CVD; cardiovascular disease; mKATP; ATP-sensitive mitochondrial potassium
Anti-diabetic functional foods as sources of insulin secreting, insulin sensitizing and insulin mimetic agents
Keywords: GLUT-1; Glucose-transporter 1; GLUT-2; Glucose-transporter 2; GLUT-3; Glucose-transporter 3; GLUT-4; Glucose transporter 4; SUR1; Sulphonylurea receptor 1; HOMA-β; Homeostasis model assessment of β-cell function; HOMA-IR; Homeostasis model assessment of
SH2 domain-containing inositol 5-phosphatase (SHIP2) regulates de-novo lipogenesis and secretion of apoB100 containing lipoproteins in HepG2 cells
Keywords: De-novo lipogenesis; VLDL; SH2 domain-containing inositol 5-phosphatase (SHIP2); Insulin resistance; HepG2; Liver; ACC; acyl COA carboxylase; FAS; fatty acid synthase; FOXO1; forkhead box protein O1; GFP; green fluorescent protein; MTP; microsomal transfe
VIP induces NF-κB1-nuclear localisation through different signalling pathways in human tumour and non-tumour prostate cells
Keywords: VIP; vasoactive intestinal peptide; EPAC; cAMP/exchange protein directly activated by cAMP; NF-κB; nuclear factor-κB; PKA; cAMP-dependent protein kinase; ERK; extracellular-signal regulated kinase; PI3-K; phosphoinositide 3-kinase; GEF; PKA-independent
Research ArticlePTPN11/Shp2 overexpression enhances liver cancer progression and predicts poor prognosis of patients
Keywords: HCC; hepatocellular carcinoma; Shp2; Src-homology 2 domain-containing phosphatase 2; DFS; disease free survival; OS; overall survival; PI3-K; phosphoinositide 3-kinase; Akt; v-akt murine thymoma viraloncogene homolog; Hepatocellular carcinoma; Shp2; Metas
Regulation of hippocampal synaptic plasticity by BDNF
Keywords: 4E-BPs; eIF4E-binding proteins; 5-HT; 5-hydroxytryptamine; ADF; actin-depolymerising factor; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; AMPAR; AMPA receptors; Arc; activity-regulated cytoskeleton-associated protein; BDNF; brain-derived n
SH2 domain-containing inositol 5-phosphatase (SHIP2) inhibition ameliorates high glucose-induced de-novo lipogenesis and VLDL production through regulating AMPK/mTOR/SREBP1 pathway and ROS production in HepG2 cells
Keywords: AMPK; AMP-activated protein kinase; ACC; Acyl COA Carboxylase; BSA; Bovine Serum Albumin; DHE; Dihydroethidium; DPI; Diphenylene iodonium; ERK; Extracellular signal-regulated kinase; FAS; Fatty Acid Synthase; FBS; Fetal bovine serum; FOXO1; Forkhead box p
The ErbB2 inhibitor Herceptin (Trastuzumab) promotes axonal outgrowth four weeks after acute nerve transection and repair
Keywords: CP; common peroneal nerve; DRG; dorsal root ganglion; NRG; neuregulin; PI3-K; phosphatidylinositol 3-kinase; s.c.; subcutaneously; Nerve regeneration; erbB2-Receptor; Herceptin/Trastuzumab; Neuregulin; Nerve injury; Peripheral nerve;
Neuroprotection elicited by P2Y13 receptors against genotoxic stress by inducing DUSP2 expression and MAPK signaling recovery
Keywords: CaMKII; calcium/calmodulin kinase II; CREB; (cAMP-response-element-binding protein)-binding protein; DAPI; 2-(4-amidinophenyl)-1H-indole-6-carboxamidine; DUSP; dual-specificity phosphatase; ERK; extracellular-signal-regulated kinase; JNK; c-Jun Kinase; 2M
BDNF mechanisms in late LTP formation: A synthesis and breakdown
Keywords: Brain-derived neurotrophic factor (BDNF); TrkB signaling; Synaptic plasticity; Long-term potentiation (LTP); Protein synthesis; Translation control; Cytoskeletal dynamics; Arc; activity-regulated cytoskeleton-associated protein; AS; Angelman syndrome; AS-
BDNF-induced local protein synthesis and synaptic plasticity
Keywords: Brain-derived neurotrophic factor (BDNF); Synaptic plasticity; Long-term potentiation (LTP); Translation; RNA transport; ADF; actin-depolymerizing factor; A2RE; heterogeneous nuclear ribonucleoprotein (hnRNP) A2 response element; Arc; activity-regulated c
PI3-kinase/Akt/mTOR signaling: Impaired on/off switches in aging, cognitive decline and Alzheimer's disease
Keywords: AD; Alzheimer's disease; Aβ; amyloid-β; APP; amyloid precursor protein; 4EBP1; eukaryotic translation initiation factor 4E (eIF-4E)-binding protein-1; FOXO; Forkhead box-O class transcription factors; FMRP; Fragile-X mental retardation protein; GSK3β;
TGF-β-induced expression of IGFBP-3 regulates IGF1R signaling in human osteosarcoma cells
Keywords: TGF-β; transforming growth factor-β; IGF; insulin-like growth factor; IGFBP-3; IGF binding protein-3; TβR; TGF-β receptor; IGF1R; type I IGF receptor; TβRII; TGF-β type II receptor; TβRI; TGF-β type I receptor; R-Smads; receptor-activated Smads; M
Inhibition of c-Jun NH2-terminal kinase stimulates mu opioid receptor expression via p38 MAPK-mediated nuclear NF-κB activation in neuronal and non-neuronal cells
Keywords: MOR; mu opioid receptor; JNK; c-Jun NH2-terminal kinase; MAPK; mitogen-activated protein kinase; MEK; mitogen-activated protein/extracellular signal-regulated kinase; NF-κB; nuclear factor-kappaB; DP; distal promoter; PP; proximal promoter; Oct-1; octame
Dolastatin, along with Celecoxib, stimulates apoptosis by a mechanism involving oxidative stress, membrane potential change and PI3-K/AKT pathway down regulation
Keywords: AKT; Celecoxib; Dolastatin; Egr-1; Molecular docking; PI3-K;
Glycogen synthase kinase-3β (GSK-3β) and its dysregulation in glioblastoma multiforme
Keywords: Cancer; Glioblastoma multiforme; GSK-3β; PI3-K; Wnt
Differential sensitivities of glioblastoma cell lines towards metabolic and signaling pathway inhibitions
Keywords: Glioblastoma; Metabolism; Warburg’s effect; PI3-K
Simvastatin-mediated enhancement of long-term potentiation is driven by farnesyl-pyrophosphate depletion and inhibition of farnesylation
Keywords: statins; isoprenoids; protein prenylation; synaptic plasticity; hippocampus; long-term potentiation; aCSF; artificial cerebral spinal fluid; AD; Alzheimer's disease; Akt; protein kinase B; fEPSPs; field excitatory postsynaptic potentials; FPP; farnesyl py
Vasoactive intestinal peptide (VIP) inhibits human renal cell carcinoma proliferation
Keywords: VIP; FPRL-1; cAMP; PI3-K; Proliferation; RCC;
PAPP-A negatively regulates ABCA1, ABCG1 and SR-B1 expression by inhibiting LXRα through the IGF-I-mediated signaling pathway
Keywords: PAPP-A; pregnancy-associated plasma protein-A; IGF-1; insulin-like growth factor 1; IGF-1R; insulin-like growth factor 1 receptor; PI3-K; phosphatidylinositol 3-kinase; Akt; Akt kinase or protein kinase B (PKB); ABCA1; ATP-binding cassette transporter A1;
Influence of cAMP and protein kinase A on neurite length from spiral ganglion neurons
Keywords: ANOVA; analysis of variance; BDNF; brain derived neurotrophic factor; CaMK; Ca2+/calmodulin-dependent protein kinase; cAMP; cyclic adenosine monophosphate; DMSO; dimethyl sulfoxide; EPAC; Exchange Protein directly Activated by Cylic AMP; FSK; forskolin;
PTEN regulates apoptotic cell death through PI3-K/Akt/GSK3β signaling pathway in DMH induced early colon carcinogenesis in rat
Keywords: Apoptosis; PI3-K; GSK-3β; Akt; PTEN; ΔΨM
Internalization and induction of antioxidant messages by microvesicles contribute to the antiapoptotic effects on human endothelial cells
Keywords: Act D; actinomycin D; ATP; adenosine triphosphate; BSA; bovine serum albumin; CMH; 1-hydroxy-3-methoxycarbonyl-2,2,5,5-tetramethylpyrrolidine; Cu/Zn-SOD; copper/zinc superoxide dismutase; CUR61414; N-((3S,5S)-1-(benzo[d][1,3]dioxol-5-ylmethyl)-5-(piperazi
Channel catfish leukocyte immune-type receptor mediated inhibition of cellular cytotoxicity is facilitated by SHP-1-dependent and -independent mechanisms
Keywords: IpLITRs; Ictalurus punctatus leukocyte immune-type receptors; SH2; Src homology 2; SHP; Src homology 2 domain-containing cytoplasmic phosphatase; Csk; C-terminal Src kinase; ITAM; immune receptor tyrosine-based activation motif; SFK; Src-family protein ty
c-Jun-dependent sulfiredoxin induction mediates BDNF protection against mitochondrial inhibition in rat cortical neurons
Keywords: Akt; ERK1/2; JNK; Neuroprotection; PI3-K; Primary cortical neurons; siRNA;
Spatial relationship of phosphorylated epidermal growth factor receptor and activated AKT in head and neck squamous cell carcinoma
Keywords: Head and neck cancer; pEGFR; pAKT; PI3-K/AKT pathway; Hypoxia; ARCON; accelerated radiotherapy with carbogen and nicotinamide; EGFR; epidermal growth factor receptor; FpAKT; fraction of pAKT positive cells; FpAKT[pEGFR]; fraction of pAKT positive cells al
Short bouts of mild-intensity physical exercise improve spatial learning and memory in aging rats: Involvement of hippocampal plasticity via AKT, CREB and BDNF signaling
Keywords: AKT; serine/threonine protein kinase; BDNF; brain-derived neurotrophic factor; CaMK-IV; Ca+2-calmodulin-dependent protein kinase type 4; CNS; central nervous system; CREB; cyclic-AMP response element binding protein; Exe; exercised; LTM; long-term memory;
Nitric oxide activates PI3-K and MAPK signalling pathways in human and rat vascular smooth muscle cells: Influence of insulin resistance and oxidative stress
Keywords: Nitric oxide; cGMP; PKG; Vascular smooth muscle cells; PI3-K; MAPK; Insulin resistance; Oxidative stress; Zucker rats;
Neuronal pentraxin 1 induction in hypoxic-ischemic neuronal death is regulated via a glycogen synthase kinase-3α/β dependent mechanism
Keywords: NP1; neuronal pentraxin 1; GSK-3α/β; glycogen synthase kinase 3α/β; Akt/PKB; protein kinase B; PI3-K; phosphatidyl inositol-3 kinase; Neuronal pentraxin 1; Hypoxic-ischemic neuronal injury; Neonatal brain injury; Neuroprotection; Glycogen synthase k
The enhanced host-cell permissiveness of human cytomegalovirus is mediated by the Ras signaling pathway
Keywords: DMEM; Dulbecco's Modified Eagle's Medium; E; Early; EBV; Epstein-Barr virus; EGF; Epidermal Growth Factor; EGFR; Epidermal Growth Factor Receptor; ERK; Extracellular Regulated Kinase; FBS; Fetal Bovine Serum; FTI; Farnesyl Transferase Inhibitor; HFF; Huma
Resolvins: Natural agonists for resolution of pulmonary inflammation
Keywords: Catabasis; Lipid mediators; Lung; Neutrophils; Omega-3; Polyunsaturated fatty acids; AA; arachidonic acid; ALI; acid lung injury; ALX/FPR2; lipoxin A4 receptor/formyl peptide receptor 2; ARDS; acute respiratory distress syndrome; ATL; aspirin-triggered li
AMP-activated kinase (AMPK)-generated signals in malignant melanoma cell growth and survival
Keywords: AICAR; 5-aminoimidazole-4-carboxamide riboside; AMPK; AMP-activated kinase; mTOR; mammalian target of rapamycin; PI3-K; phosphatidylinositol 3-kinase; AMP-activated kinase (AMPK); Malignant melanoma; 5-Aminoimidazole-4-carboxamide riboside (AICAR); Metfor
Role of IRS-4 in PI3-K activation by insulin in HepG2 cells, modulation by Angiotensin II
Keywords: Ang II–Insulin cross-talk; IRS-4 tyr-phosphorylation; AT1 receptors; PI3-K
Herpesviruses: Hijacking the Ras signaling pathway
Keywords: BL; Burkitt's lymphoma; COX-2; cytochrome c oxidase subunit II; E; Early; EBNA; Epstein-Barr nuclear antigen; EBV; Epstein-Barr virus; EGF; Epidermal Growth Factor; EGFR; Epidermal Growth Factor Receptor; Elk; Ets-related transcription factor; ERK; ex
Estrogen receptor alpha and G-protein coupled receptor 30 mediate the neuroprotective effects of 17β-estradiol in novel murine hippocampal cell models
Keywords: glutamate; immortalization; cell biology; signal transduction; hippocampus; membrane estrogen receptor; Akt; homologous enzyme sequence of viral oncogene v-akt isolated from AKR mouse spontaneous thymoma cell line and also called protein kinase B; AR; and
Cloning of a centaurin-α1 like gene MjCent involved in WSSV infection from shrimp Marsupeneaus japonicus
Keywords: Marsupeneaus japonicus; WSSV; centaurin-α1; PI3-K; ARF6; GAP; virus;
The PI3-K/AKT-Pathway and Radiation Resistance Mechanisms in Non-small Cell Lung Cancer
Keywords: Non-small cell lung cancer; Radiotherapy; PI3-K; AKT; EGFR