Alpha-synuclein transgenic mice display age-related slowing of gastrointestinal motility associated with transgene expression in the vagal system

► α-Synuclein transgenic mice display age-related gastrointestinal dysfunction. ► GI α-synuclein was restricted to efferent vagus nerve terminals from the DMV. ► DMV dysfunction is a plausible mediator of GI symptoms in Parkinson disease.