Wide therapeutic time-window of low-frequency stimulation at the subiculum for temporal lobe epilepsy treatment in rats

► One Hz stimulation of the subiculum inhibits both kindling and kindled seizures. ► This antiepileptic effect shows wider time-window than stimulating other targets. ► This treatment abolishes pilocarpine-induced spontaneous seizures. ► This treatment does not show time-dependent property in pilocarpine model. ► This antiepileptic effect shows frequency-dependent characteristic.