Mitochondrial oxidative stress and epilepsy in SOD2 deficient mice: Attenuation by a lipophilic metalloporphyrin

►The role of mitochondrial oxidative stress in epilepsy was investigated. ►Mice deficient in mitochondrial antioxidant (Sod2−/−) showed spontaneous electrographic and motor seizures. ►Seizures, oxidative stress and bioenergetic parameters in Sod2−/− mice were attenuated by a catalytic antioxidant. ►Mitochondrial oxidative stress is a contributing mechanism to epilepsy in Sod2-/- mice.