Synaptic dysfunction in genetic models of Parkinson's disease: A role for autophagy?

►Reviews the literature on synaptic dysfunction in LRRK2, parkin & α-synuclein models. ►Altered synaptic vesicle/endosome trafficking implicated in Parkinson disease models. ►Macroautophagy is observed in somatic and neuritic compartments of stressed neurons. ►The potential impact of neuritic autophagy on synaptic function remains unexplored.