Autism with Seizures and Intellectual Disability: Possible Causative Role of Gain-of-function of the Inwardly-Rectifying K+ Channel Kir4.1

►Mutations of KCNJ10 contribute to autism with seizures and intellectual disability ►Functionally, these mutations act through a gain-of-function of the Kir4.1 channel ►The phenotype suggests that mutations affect K+ homeostasis mainly in the brain