Excitotoxicity through Ca2+-permeable AMPA receptors requires Ca2+-dependent JNK activation

►Excitotoxicity mediated by GluA4-containing Ca-AMPARs involves the JNK pathway. ►Activation of the JNK pathway downstream of Ca-AMPARs is Ca2+-dependent. ►In the rat hippocampus the GluA4 subunit may interact with the JNK scaffold JIP-1. ►The interaction with GluA4 occurs through the N-terminal domain of JIP-1.