کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6022829 1580694 2011 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mechanism mediating oligomeric Aβ clearance by naïve primary microglia
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Mechanism mediating oligomeric Aβ clearance by naïve primary microglia
چکیده انگلیسی
►Naïve primary microglia internalized oligomeric amyloid-β peptide (oAβ) in a time- and dose-dependent manner. ►Knockdown of scavenger receptor type-A, but not CD36 by small interfering RNAs (siRNAs) attenuated oAβ internalization by primary microglia. ►Lysosomal cysteine protease including cathepsin B, but neither serine nor aspartate proteases, degraded internalized oAβ by primary microglia. ►Epoxomicin, a specific proteasome inhibitor, failed to prevent oAβ degradation in microglia. ►Neprilysin, matrix metalloproteinases, and insulin degrading enzyme were not involved in oAβ degradation in microglia.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Disease - Volume 42, Issue 3, June 2011, Pages 221-230
نویسندگان
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