Forebrain CRHR1 deficiency attenuates chronic stress-induced cognitive deficits and dendritic remodeling

►Forebrain CRHR1 deficiency attenuates memory impairments induced by chronic stress. ►Forebrain CRHR1 inactivation prevents chronic stress-induced CA3 dendritic shrinkage. ►Nectin-3 is associated with stress-induced structural changes and memory loss. ►CRHR1 interacts with chronic stress to regulate endocrine and metabolic function.