Nanoceria extend photoreceptor cell lifespan in tubby mice by modulation of apoptosis/survival signaling pathways

► There are currently no successful treatments for inherited retinal degeneration. ► Reactive oxygen species are common to all neurodegenerative diseases. ► Nanoceria destroy ROS and slow inherited retinal degeneration in tubby mice. ► Nanoceria may slow progression of macular degeneration and diabetic retinopathy. ► Nanoceria may also be therapeutically beneficial in many ocular diseases.