Worsening of Huntington disease phenotype in CB1 receptor knockout mice

► Loss of CB1R expression worsens motor performance and increases striatal aggregates in HD mice. ► Loss of CB1R expression worsens motor performance and increases striatal lesions induced by 3NP intoxication. ► Results support that early loss of CB1 receptors seen in HD is involved in the pathophysiological development of this disorder.