کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6022893 | 1580691 | 2011 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
[F-18]FDDNP microPET imaging correlates with brain Aβ burden in a transgenic rat model of Alzheimer disease: Effects of aging, in vivo blockade, and anti-Aβ antibody treatment
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
عصب شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: [F-18]FDDNP microPET imaging correlates with brain Aβ burden in a transgenic rat model of Alzheimer disease: Effects of aging, in vivo blockade, and anti-Aβ antibody treatment [F-18]FDDNP microPET imaging correlates with brain Aβ burden in a transgenic rat model of Alzheimer disease: Effects of aging, in vivo blockade, and anti-Aβ antibody treatment](/preview/png/6022893.png)
چکیده انگلیسی
⺠[F-18]FDDNP microPET imaging in a transgenic rat model of Alzheimer's disease. ⺠β-amyloid (Aβ) levels correlate with [F-18]FDDNP signal and increase with age. ⺠[F-18]FDDNP labels both diffuse and fibrillar Aβ plaques. ⺠Naproxen pre-treatment reversibly blocks [F-18]FDDNP binding. ⺠Intracranial anti-Aβ antibody delivery decreases Aβ levels and [F-18]FDDNP signal.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Disease - Volume 43, Issue 3, September 2011, Pages 565-575
Journal: Neurobiology of Disease - Volume 43, Issue 3, September 2011, Pages 565-575
نویسندگان
Edmond Teng, Vladimir Kepe, Sally A. Frautschy, Jie Liu, Nagichettiar Satyamurthy, Fusheng Yang, Ping-Ping Chen, Graham B. Cole, Mychica R. Jones, Sung-Cheng Huang, Dorothy G. Flood, Stephen P. Trusko, Gary W. Small, Gregory M. Cole, Jorge R. Barrio,