[F-18]FDDNP microPET imaging correlates with brain Aβ burden in a transgenic rat model of Alzheimer disease: Effects of aging, in vivo blockade, and anti-Aβ antibody treatment

► [F-18]FDDNP microPET imaging in a transgenic rat model of Alzheimer's disease. ► β-amyloid (Aβ) levels correlate with [F-18]FDDNP signal and increase with age. ► [F-18]FDDNP labels both diffuse and fibrillar Aβ plaques. ► Naproxen pre-treatment reversibly blocks [F-18]FDDNP binding. ► Intracranial anti-Aβ antibody delivery decreases Aβ levels and [F-18]FDDNP signal.